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| Tuesday, October 11th , 2050 |
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| RP Justin Sturdivant retired from professional baseball. |
| Activated 3B Clement Pecchia from the injured list. |
| Wednesday, September 21st , 2050 |
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| Activated CF Bryce Elliott from the injured list. |
| Thursday, September 15th , 2050 |
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| Placed 3B Clement Pecchia on the 7-day injured list, retroactive to 09/14/2050. |
| Wednesday, August 31st , 2050 |
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| Activated SP Jason Carrillo from the injured list. |
| Wednesday, August 10th , 2050 |
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| Placed CF Bryce Elliott on the 7-day injured list, retroactive to 08/09/2050. |
| Thursday, August 4th , 2050 |
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| Activated LF Jeremy Attaway from the injured list. |
| Friday, July 29th , 2050 |
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| Placed SP Jason Carrillo on the 7-day injured list, retroactive to 07/28/2050. |
| Sunday, June 26th , 2050 |
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| Placed LF Jeremy Attaway on the 7-day injured list, retroactive to 06/25/2050. |
| Tuesday, June 14th , 2050 |
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| Activated C Nate Jacobson from the restricted list. |
| Friday, June 10th , 2050 |
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| Placed C Nate Jacobson on the restricted list. |
| Monday, April 4th , 2050 |
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| Promoted C Andrew Cunningham to Major League Arizona. |
| Received RP Jason Caywood from Major League Arizona. |
| Received CL Frank Blythe from Double A Tucson. |
| Received RP Hector Gutierrez from Rookie League Nogales. |
| Received RP Tyler Reid from Double A Tucson. |
| Received RP Yuji Yamauchi from Double A Tucson. |
| Received SP Jimmy Little from Double A Tucson. |
| Received C Nate Jacobson from Major League Arizona. |
| Received RF Dan Donaldson from Major League Arizona. |
| Received 2B Pat Brown from Major League Arizona. |
| Received RF Matt Leslie from Major League Arizona. |
| Received LF Chris Moller from Major League Arizona. |
| Received 2B Kyle Gibbons from Major League Arizona. |
| Received CF Bryce Elliott from Double A Tucson. |
| Received LF Jeremy Attaway from Double A Tucson. |
| Received 1B Chris LaFromboise from Double A Tucson. |
| Received SS Jim Toman from Double A Tucson. |
| Demoted SP Luis Padilla to Double A Tucson. |
| Demoted 3B Steve Weinberger to Double A Tucson. |
| Demoted RF Jason Thomas to Double A Tucson. |
| Monday, March 14th , 2050 |
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| Promoted 2B Pat Brown to Major League Arizona. |
| Promoted LF Chris Moller to Major League Arizona. |
| Promoted 1B Bobby Garcia to Major League Arizona. |
| Promoted RF Dan Donaldson to Major League Arizona. |
| Promoted 2B Chris Odeneal to Major League Arizona. |
| Promoted 2B Alex Fernandez to Major League Arizona. |
| Promoted 2B Kyle Gibbons to Major League Arizona. |
| Promoted RF Matt Leslie to Major League Arizona. |
| Promoted C Nate Jacobson to Major League Arizona. |
| Promoted RP Jason Caywood to Major League Arizona. |
