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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Player | From-To | W | L | Pct | ERA | G | GS | CG | SHO | SV | IP | H | ER | HR | BB | SO |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Joe O'Born | 2053-2053 | 3 | 3 | .500 | 5.82 | 6 | 6 | 0 | 0 | 0 | 34.0 | 36 | 22 | 7 | 19 | 30 |
| Gabe O'Connor | 2029-2044 | 35 | 43 | .449 | 3.14 | 533 | 2 | 0 | 0 | 170 | 705.1 | 658 | 246 | 54 | 185 | 772 |
| Dan O'Keeffe | 2030-2045 | 165 | 176 | .484 | 3.80 | 460 | 453 | 54 | 16 | 0 | 3057.0 | 3159 | 1292 | 246 | 483 | 2862 |
| Dan O'Meara | 2051-2053 | 4 | 7 | .364 | 4.04 | 87 | 3 | 0 | 0 | 1 | 164.2 | 133 | 74 | 26 | 85 | 141 |
| Phil O'Sullivan | 2018-2021 | 8 | 30 | .211 | 5.62 | 65 | 47 | 2 | 0 | 0 | 312.1 | 385 | 195 | 50 | 119 | 170 |
| Luke Oates | 2052-2053 | 1 | 2 | .333 | 5.62 | 12 | 0 | 0 | 0 | 0 | 16.0 | 13 | 10 | 2 | 13 | 12 |
| Tim Ocampo | 2043-2053 | 64 | 107 | .374 | 4.43 | 425 | 156 | 6 | 1 | 67 | 1337.1 | 1466 | 658 | 137 | 459 | 1180 |
| Vinny Ochoa | 2049-2052 | 8 | 7 | .533 | 5.51 | 102 | 1 | 0 | 0 | 4 | 163.1 | 196 | 100 | 42 | 52 | 183 |
| Willie Ochoa | 2022-2023 | 1 | 0 | 1.000 | 5.65 | 13 | 0 | 0 | 0 | 0 | 14.1 | 11 | 9 | 0 | 8 | 7 |
| Chris Odeneal | 2046-2052 | 5 | 14 | .263 | 7.32 | 55 | 15 | 2 | 0 | 0 | 173.1 | 218 | 141 | 45 | 79 | 161 |
| Jon Ogden | 2035-2043 | 23 | 30 | .434 | 3.84 | 207 | 61 | 0 | 0 | 7 | 523.0 | 480 | 223 | 56 | 190 | 612 |
| Billy Olivares | 2026-2029 | 5 | 42 | .106 | 7.02 | 63 | 63 | 2 | 0 | 0 | 320.1 | 446 | 250 | 54 | 125 | 204 |
| Angel Olmedo | 2019-2021 | 1 | 0 | 1.000 | 4.05 | 9 | 1 | 0 | 0 | 0 | 20.0 | 21 | 9 | 0 | 14 | 16 |
| Matt Olson | 2018-2018 | 0 | 0 | .000 | 13.50 | 3 | 0 | 0 | 0 | 0 | 1.1 | 3 | 2 | 1 | 1 | 1 |
| Nelson Orama | 2050-2050 | 2 | 3 | .400 | 5.17 | 28 | 3 | 0 | 0 | 0 | 55.2 | 51 | 32 | 9 | 25 | 55 |
| Tony Orellana | 2050-2053 | 8 | 10 | .444 | 3.15 | 117 | 0 | 0 | 0 | 42 | 125.2 | 97 | 44 | 11 | 53 | 144 |
| Alex Ornelas | 2024-2035 | 0 | 0 | .000 | 0.00 | 1 | 0 | 0 | 0 | 0 | 0.1 | 0 | 0 | 0 | 1 | 1 |
| Mike Orr | 2035-2044 | 48 | 36 | .571 | 4.23 | 201 | 96 | 6 | 4 | 0 | 754.2 | 818 | 355 | 69 | 217 | 822 |
| Gabe Ortiz | 2018-2019 | 20 | 23 | .465 | 4.37 | 73 | 61 | 5 | 4 | 0 | 379.1 | 412 | 184 | 42 | 61 | 227 |
| Jose Osuna | 2023-2029 | 20 | 20 | .500 | 4.41 | 384 | 0 | 0 | 0 | 38 | 346.2 | 360 | 170 | 52 | 96 | 426 |
| Jason Ottem | 2022-2025 | 2 | 0 | 1.000 | 5.76 | 46 | 0 | 0 | 0 | 1 | 45.1 | 66 | 29 | 7 | 25 | 27 |
| Shuhei Ouchi | 2048-2053 | 69 | 44 | .611 | 4.09 | 155 | 152 | 4 | 1 | 0 | 950.0 | 959 | 432 | 142 | 253 | 937 |
